Hospital air purification

Hospital Air Purification: Two-Stage HEPA and Washable Metal-Foam Filtration

A washable metal-foam pre-filter protects a HEPA filter that captures at least 99.97% of 0.3 µm particles, including bacteria, spores and virus-carrying aerosols. Fewer HEPA changes, less filter waste, and optional carbon for nuclear medicine.

Metal foam + HEPA Third-party tested >99.99% Variable-speed fan Washable pre-filter Updated September 2026

Quick answer

Iodine Air Systems hospital units use two-stage physical filtration: a washable open-cell metal-foam pre-filter followed by a HEPA filter, which by definition captures at least 99.97% of particles at 0.3 µm. That is the hardest size to catch; bacteria, fungal spores and virus-carrying aerosols are captured with even higher efficiency. The metal-foam stage takes the coarse dust load, so the HEPA filter lasts longer and less filter waste is created. Activated carbon can be added for nuclear medicine and I-131 areas. We describe performance as capture, backed by a third-party whole-unit test (>99.99% for particles ≥0.3 µm), and make no pathogen-kill claims.

≥99.97%HEPA capture at 0.3 µm (DOE definition)
2 stagesMetal-foam pre-filter + HEPA
WashableMetal-foam pre-filter is cleaned and reused
>99.99%Third-party whole-unit test, particles ≥0.3 µm

How two-stage filtration works

STAGE 1

Washable metal-foam pre-filter

An open-cell metal foam holds back coarse dust, lint, hair and larger particles before they reach the HEPA filter. It is cleaned and reused instead of discarded.

STAGE 2

HEPA filter

Captures at least 99.97% of particles at 0.3 µm, the most penetrating size, and captures larger and smaller particles with higher efficiency. Our IAS-NC500-HI-CUSTOM passed a third-party whole-unit test at >99.99% for particles ≥0.3 µm.

OPTIONAL STAGE 3

Activated carbon

Impregnated carbon for radioiodine in nuclear medicine and I-131 therapy areas, or for odors and gases.

Third-party tested: >99.99% for particles ≥0.3 µm

Third-party test result
The IAS-NC500-HI-CUSTOM, fitted with a washable metal-foam pre-filter and a HEPA filter, was tested as a complete unit by the National Center of Quality Inspection and Testing on Air Purification Products (Guangzhou Institute of Microbiology Group) using the ducted air-purification device method of GB/T 18801-2022 Annex L. Particle filtration efficiency was greater than 99.99% for KCl aerosol particles of 0.3 µm and larger (report KJ2026002491, issued September 4, 2026). The report is available on request.
Tested unitIAS-NC500-HI-CUSTOM (metal-foam pre-filter + HEPA), complete unit
LaboratoryNational Center of Quality Inspection and Testing on Air Purification Products (Guangzhou Institute of Microbiology Group)
MethodGB/T 18801-2022 Annex L, ducted air-purification device, particle filtration efficiency
Test aerosol / particle sizeKCl / ≥0.3 µm
Result>99.99%
ReportKJ2026002491, issued September 4, 2026 (available on request)
Test conditions24.6 °C, 59% RH; fan on variable-frequency drive

The result applies to the tested model. It is a whole-unit efficiency for particles ≥0.3 µm, which includes housing and seal leakage; it is a different measurement from a HEPA media rating at 0.3 µm.

Variable-speed, adjustable airflow

The fan runs on a variable-frequency drive, so airflow can be set to the room and the task: higher for construction containment or surge use, lower for quiet operation in occupied areas. Built-in differential pressure gauges show filter loading at any speed.

Pathogen sizes versus what HEPA captures

Pathogens are much larger than gas molecules and are captured by physical filtration. The table shows typical sizes and why HEPA handles them. The 0.3 µm point is where HEPA is least efficient, and it is still at least 99.97%.

ParticleTypical sizeHEPA performance
Fungal spores (e.g. Aspergillus conidia)about 2–3 µm and largerCaptured by HEPA with very high efficiency
Bacteriaabout 0.5–5 µmCaptured by HEPA with very high efficiency
Respiratory droplets and aerosols carrying virusesmostly larger than 0.3 µm; smallest nuclei below 1 µmCaptured by HEPA; 0.3 µm is the hardest size and is still ≥99.97%
Individual virus particlesabout 0.02–0.3 µmRarely airborne on their own; below 0.3 µm HEPA efficiency rises again (diffusion)
Most-penetrating particle size (MPPS)≈0.3 µmThe HEPA rating point: ≥99.97%
Capture, not kill. Filtration removes pathogens from the air and holds them on the filter. It does not kill them. That is why used filters are handled with bagging and PPE, and why we do not claim pathogen inactivation. In the US, products that claim to kill or inactivate microorganisms are regulated by the EPA as pesticides or pesticide devices.

Why the metal-foam pre-filter lowers running cost

Actual HEPA life depends on dust load, airflow and operating hours. We set replacement by differential pressure, measured on gauges built into the unit. Learn more about open-cell metal foam at PrometheanFoam.

Cleaning the pre-filter safely

  1. Switch the unit off and let the fan stop.
  2. Remove the pre-filter and place it straight into a bag at the unit.
  3. Wear the PPE your infection-prevention policy requires for handling used filter media.
  4. Wash and dry the pre-filter in a designated area, then inspect it and reinstall.
  5. Record the cleaning and the HEPA differential pressure reading.

Radioactive areas

Pre-filters from nuclear medicine or I-131 areas are not washed, because the wash water would carry radioactive contamination. They are surveyed and handled under your radiation protection program.

Where hospitals use these units

Permanent ventilation, pressure relationships and filter efficiencies for each space are set by ASHRAE 170 as adopted by your authority having jurisdiction. See what changed in ASHRAE 170-2025 and ASHRAE 241 vs 170.

ASHRAE 241 and clean airflow

ASHRAE 241, Control of Infectious Aerosols, sets an equivalent clean airflow (ECAi) target for infection risk management mode. Outdoor air, filtration and air cleaning can all contribute. For a filtration unit, the contribution is based on its airflow and filter efficiency. We provide those figures for each unit so your design engineer can include them in the 241 assessment. Whether a space meets 241 is determined by that assessment, not by any single product.

Products and services

Hospital air purification FAQ

What is the two-stage filtration in Iodine Air Systems hospital units?

Stage 1 is a washable open-cell metal-foam pre-filter that holds back coarse dust, lint and larger particles. Stage 2 is a HEPA filter, which by the US Department of Energy definition captures at least 99.97% of particles at 0.3 µm. Activated carbon can be added as a third stage for radioiodine in nuclear medicine areas or for odors and gases.

Why add a metal-foam pre-filter in front of the HEPA filter?

The pre-filter takes the coarse dust load that would otherwise clog the HEPA filter. The HEPA filter stays cleaner for longer, so it is replaced less often and there is less filter waste. The metal-foam pre-filter itself is cleaned and reused instead of thrown away.

Does HEPA filtration capture bacteria and viruses?

Yes. The EPA notes that a HEPA filter can remove at least 99.97% of airborne particles of 0.3 µm, including bacteria and mold, and that larger and smaller particles are trapped with even higher efficiency. Airborne viruses travel mostly in droplets and aerosols larger than individual virus particles.

Do your units kill or inactivate pathogens?

No. Our hospital units remove particles from the air by physical filtration: the pathogens are captured, not killed. We describe performance as capture efficiency backed by a third-party whole-unit test, and we do not make kill or inactivation claims.

How is the metal-foam pre-filter cleaned in a hospital?

Following a written procedure: remove the pre-filter with the unit off, bag it at the unit, wear the PPE your infection-prevention policy requires, and wash and dry it in a designated area before reinstalling. Treat captured material as potentially infectious. Pre-filters from radioactive areas such as I-131 rooms are not washed; they are handled under your radiation protection program.

Has the unit been tested by a third party?

The IAS-NC500-HI-CUSTOM, fitted with a washable metal-foam pre-filter and a HEPA filter, was tested as a complete unit by the National Center of Quality Inspection and Testing on Air Purification Products (Guangzhou Institute of Microbiology Group) using the ducted air-purification device method of GB/T 18801-2022 Annex L. Particle filtration efficiency was greater than 99.99% for KCl aerosol particles of 0.3 µm and larger (report KJ2026002491, issued September 4, 2026). The report is available on request.

Can the airflow be adjusted?

Yes. The fan runs on a variable-frequency drive, so airflow can be set for each room and task, for example higher for construction containment and lower for quiet operation in occupied areas.

Is HEPA filter replacement still needed?

Yes. The pre-filter extends HEPA life but does not replace it. Replace the HEPA filter when its differential pressure reaches the set limit or at your scheduled interval, using your facility's normal PPE and bagging procedure for used HEPA filters.

Do your units help with ASHRAE 241?

ASHRAE 241 lets filtration and air cleaning count toward the equivalent clean airflow (ECAi) a room needs in infection risk management mode. We calculate the clean airflow each unit contributes to your rooms from its airflow and filter efficiency, for your design engineer to include in the 241 assessment.

Which hospital spaces are these units used in?

Nuclear medicine and I-131 therapy areas (with activated carbon), construction and renovation containment, airborne infection isolation support, emergency department and waiting areas, and other spaces where the design engineer calls for additional HEPA filtration. Permanent ventilation for each space must still meet ASHRAE 170 as adopted by your AHJ.

Can you build a custom unit for our hospital?

Yes. Through our OEM and custom manufacturing service we build units to your airflow, size, power and filtration requirements, including built-in differential pressure gauges and HEPA test ports.

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